Back to ListHypophyseal Hormone Infusion Pump

La Fenice Hypophyseal Hormone Infusion Pump

GnRH pulse pump is the innovative technology in China market
It works through the continuous administration of GnRH "desensitized" the hypothalamus and pituitary gland. LH and FSH are only released by the pituitary gland if GnRH is released in pulses or short bursts, usually at 90 to 120 minute intervals. LH and FSH then target the gonads, causing the development and maturation egg cells in female or sperm in the male.
GnRH pump is a battery-powered device much like an insulin pump. It is essentially a "high tech" needle and syringe arrangement containing a supply of GnRH.
GnRH Infusion Pump is designed to meet the needs of Chinese physicians and patients for the treatment of Idiopathic Hypogonadotropic Hypogonadism (IHH) which is also known as Kallmann Syndrome. Equipped with pulse infusion via micro pump technology, GnRH infusion pump stimulates hypophysis to excrete Follicle-Stimulating Hormone (FSH)/ luteinizing hormone(LH) by simulating pulse excretion of human gonadotropin-releasing hormone(GnRH) in order to make patients recover from abnormally physiological regulated function.
Kallmann syndrome is a genetic disorder marked by anosmia and hypogonadism. Abnormalities in various genes may cause a defect in the hypothalamus, causing a deficiency of gonadotropin-releasing hormone (GnRH); this in turn causes deficiency in FSH and LH levels. Kallmann syndrome is also called hypothalamic hypogonadism. GnRHpulse infusion have a significant effect on maintaining and increasing in secondary sex characters, a progressive improvement of deficiency of grown-up Growth Hormone (GH)and bone mineral density (BMD), makes a contribution to regain fertility, and reduces the risk of cardiovascular-related adverse events, which is the most ideal treatment for such disease in these days.
Introduction of IHH and GnRH Infusion Pump
IHH (IndiopathicHypogonadotropicHypogonadism) is characterized by low gonadotropin levels, absence of LH and FSH pulses, low sex steroid hormone levels, delay in or complete failure to undergo puberty, and finally result in infertility. By definition, either anosmia (lack of sense of smell) or severe hyposmia is present in patients with Kallmann syndrome.
Connection between Puberty and IHHP Athogenesis
Puberty is initiated by hormonal signals from the brain to the gonads and marked by the pulsatileGnRH, with a 60-90 minutes release cycle which may increase gradually with age until the peak pulses become regular on a daily basis.
Low-frequency GnRH pulses lead to FSH release, whereas high-frequency GnRH pulses stimulate LH release.The function of LH is to stimulate the production of sex hormones, from the ovaries in women and from the testicles, or testes, in men. And the FSH controls sperm and ovarian follicle production.
Delay of the puberty with deficient secondary sex characters can result in infertility.

The best IHH Therapy
IHH can be treated by GnRH, gonadotropin or testosterone therapy. Pulsatile GnRHtherapy is the best for those with a hypothalamic failure.
Therapeutic Effect
The LH and FSH levels would rise significantly with pulse waves in the pulse injection three days after the GnRH therapy.
The patient would begin to undergo puberty after 12 weeks (LH/FSH>0.7). And the sexual characteristic would appear with regular and steady releasing of LH and FSH.
After 24 weeks of treatment, thetesticular volume and sperm count would increase with the improvement of sexual desire for male.
The first menstruation (menarche) would occur 100 days after the treatment for female, and the menstrual periods gradually become normal.
During the period of 6-9 months, the obvious curative effect would become prominent through the change of secondary sex characters of the patients.
Currently, some of our patients who had undergone the treatment have successfullybecome pregnant already.